Our everyday actions, from decision making to motor control, are thought to involve information exchange through transient neural synchrony across multiple brain regions. Emerging evidence suggests that a range of neurological disorders such as Parkinson’s disease and essential tremor could be attributed to dysfunction of this fundamental neural property. Deep brain stimulation is commonly used to reduce disease symptoms by delivering high frequency electrical pulses to key brain regions. A new stimulation strategy, called phase-specific deep brain stimulation, aims to selectively regulate neural synchrony. I will highlight some experimental results which show the effect of phase-specific deep brain stimulation for the treatment of patients with pathological tremor and discuss how dynamic causal modelling could be used to infer effect of stimulation on disease circuit.